Natalie and her friends have saved Earth and its inhabitants from vampire, clone and alien invasions, yet their task still isn't finished. She and her small army of vampires must eradicate yet another undead horde. Her dreams have given her hints and clues about their new enemies, but they are still largely a mystery.
Nat has been advised by Fate itself that the new undead creatures are only part of the final task that she must face. The greatest threat to humanity still awaits. This time, she must conquer it alone. The ordeals that Natalie has suffered in the past have given her the power to overcome this new and final menace, if only she can figure out how to utilize her talents to their fullest.